Seeing how amazing Mass Effect 2 looks at E3, I got interested enough to dust off ME for another playthrough, mostly to see if I could get the Paramour achievement. 
I have to say this game is just gorgeous - there are some rendering issues and pop-in, but in general it just looks glorious.
I am also still dazzled by what a rich, complicated universe Bioware created. The different alien races, all unique but all with a sensible history, a different take on how species could evolve. I really liked the conversation with Liara when they discuss the fact that perhaps the reason humans are so reckless and brazen is that we don't have time to be polite. Some really interesting commentary on what humanity and our evolution is all about.
One thing still sticks in my craw, though - the elaborateness of the Reaper plan. It strikes me as incredibly stupid and unnecessarily complicated. These guys have advanced technology and mind control, and they haven't mastered farming? I mean that's what we're talking about here. Why do they plunder and retreat? Why not set up a bunch of worlds that are continually generating animals for eating? And why not cultivate animals that aren't likely to fight back? There's a reason we farm cows and not monkeys: cows produce lots of meat and are dumb dumb dumb.