Both of them were pretty funny, one doesnt stand out from the other as in being a good movie , they both make humor out of different things, like In Chuck and Larry all the humor was focused around gay stuff' and in Knocked up it was Stupid Humor and (to me) cussing humor.

The comedy in Chuck and Larry was more stretched out throughout the whole movie, while knocked up at a lot of key parts and had more of a story.

My Ratings:

I now pronounce you Chuck and Larry - 9.1

Knocked Up - 8.9

Now I just need to get and see the Simpsons movie!