I got sick of my stealth character on Oblivion. The two main problems I ran into was how tedious the process was of poisoning the weapon, repairing the weapon, making potions etc., after every fight and also the fact that if I conjure something I lose my surprise attack as well as my creature is in the way of my line of fire. So...
I am starting again as a combo mage/fighter. I'm having really good luck with making my own spell of drain health. Even though I didn't take destruction as a major skill (I'm also trying to powerlevel), I take most stuff down with one hit. I take my best blade, blunt, and bow weapons with me at all times on work on whatever skill is the lowest. Whenever I get bored with that (or run into something hard to kill) I switch to spells. I am wearing the best armor I can find (heavy or light), I do quests as I find them, and I'm not worried about doing the main quest first. When I find a new location, I empty it. I only fast travel if I've been there before, and I hope to complete every quest in the game with this character. Strong from the start and strong at the finish hopefully too. I will update this blog with more stats and news later.