Actor
| 1. | The Spiderwick Chronicles (2008) | |
| 2. | The Assassination of Jesse James by the Coward Robert Ford (2007) | |
| 3. | Romance & Cigarettes (2005) | |
| 4. | Saved! (2004) as Lilian | |
| 5. | The Best Thief in the World (2004) as Sue | |
| 6. | Red Dragon (2002) as Molly Graham | |
| 7. | Pipe Dream (2002) as Toni Edelman | |
| 8. | Let the Devil Wear Black (1999) as Julia Hirsch | |
| 9. | The Five Senses (1999) as Rona | |
| 10. | Goodbye Lover (1999) as Peggy Blane | |
| 11. | The Portrait of a Lady (1996) as Henrietta Stackpole | |
| 12. | Boys on the Side (1995) as Robin | |
| 13. | The Client (1994) as Dianne Sway | |
| 14. | Bullets Over Broadway (1994) as Ellen | |
| 15. | Mr. Wonderful (1993) | |
| 16. | Naked In New York (1993) as Joanne White | |
| 17. | Fried Green Tomatoes (1991) as Ruth Jameson | |
| 18. | Grand Canyon (1991) as Dee | |
| 19. | Longtime Companion (1990) | |
| 20. | Reckless (1984) as Pooty |
Most Popular Films with Mary-Louise Parker
| 1. | Longtime Companion | 1990 |
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| 2. | The Spiderwick Chronicles | 2008 |
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| 3. | Jesse James | 2007 |
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| 4. | Pipe Dream | 2002 |
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| 5. | Boys on the Side | 1995 |
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| 6. | Goodbye Lover | 1999 |
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| 7. | The Best Thief in the World | 2004 |
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| 8. | Grand Canyon | 1991 |
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| 9. | Romance & Cigarettes | 2005 |
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| 10. | Saved! | 2004 |
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