- He appeared in the Naked Brothers Band episode "Nat is a Stand-up Guy."
- George was listed at #73 in Forbes magazine's Celebrity 100 of 2007.
- George is good friends with Michael Wolff and Polly Draper.
- He has a DVD out called Why Are You Crying?.
- He has starred in movies such as The Adventures of Sharkboy and Lavagirl 3-D, Outta Time and Real Women Have Curves.
- In a 2005 interview with Howard Stern, he claimed that he and Carlos Mencia were involved in a physical altercation at a comedy club. Lopez alleged that Mencia appropriated 13 minutes of Lopez' material without permission for his HBO comedy special.
- He was a featured celebrity golfer in The 2004 Chrysler Bob Hope Classic and the 2004 AT&T Pebble Beach Pro-Am. He and his pro partner finished third in the Pebble Beach event. George was the top ranking celebrity at completion of the golf tournament.
- In August 2005, Time magazine named him as one of the Top 25 Most Influential Hispanics In America.
- He likes to play a lot of golf.
- He has never known who his real father was.
- He suffers from a genetic defect which causes his kidneys to malfunction. In April 2005, he received a transplanted kidney from his Cuban-American wife, Ann; they have been married since 1993 and have a daughter, Mayan, born in 1996.
- In a 2005 interview by Howard Stern, he claimed that he and Carlos Mencia were involved in a physical altercation at a comedy club. Lopez alleged that Mencia appropriated 13 minutes of Lopez' material without permission for his HBO comedy special.
- As of 2006 he is only the fourth Latino ever to head a sitcom, the first two being Desi Arnaz ("I Love Lucy" (1951)), Freddie Prinze ("Chico and the Man" (1974)) and Paul Rodriguez ("a.k.a. Pablo" (1984)).
- He received a star on the Hollywood Walk of Fame (March 29, 2006).
- On April 25, 2005, he had a successful kidney transplant surgery using an organ donated by his wife, Ana Serrano.
- George Lopez's character on George Lopez (2002) was ranked #18 in TV Guide's list of the "50 Greatest TV Dads of All Time" (June 20, 2004 issue).
- His 2003 live comedy album, "Team Leader", was nominated for the "Best Comedy Album" Grammy in 2004, up against albums by Garrison Keillor, ''Weird Al' Yankovic', Margaret Cho and David Cross.
- In October 2003, he became one of the few comedians to be able to sell-out Los Angeles' historic Universal Amphitheater for three straight nights (Oct. 10-12).
- Sandra Bullock gave George his break into TV stardom with her own production company when she sent out a scout to check the clubs for Latino talent because there were no Hispanic shows on TV.
- He is a disc jockey on MEGA 92.3 in Los Angeles.
- Turned down a role in Desperado because he didn't want to be in films that promoted negative images of Latinos.
- He plays the song "Low Rider" before doing shows.
- He's 5'10".
- This is the first Latino show to have more than 90 episodes (5 seasons), the record is 4 episodes.
- Only the fourth Latino ever to head a sitcom, the first two being Desi Arnaz (I Love Lucy), Freddie Prinze (Chico and the Man), and Paul Rodriguez (AKA Pablo).
- He had a successful kidney transplant surgery using an organ donated by his wife, Ann.
- He was one of the many witnesses in the Michael Jackson trial.
- In October 2003, he became one of the few comedians to be able to sell-out Los Angeles' historic Universal Amphitheater for three straight nights (Oct. 10-12)
- Sandra Bullock gave George his break into TV stardom with her own production company when she sent out a scout to check the clubs for Latino talent because there were no Hispanic shows on TV.
- He turned down a role in Desperado because he didn't want to be in films that promoted negative images of Latinos.
