- Bill appeared in TV commercials for Ballard Computer in the late 80s-early 90s.
- While working on Bill Nye The Science Guy Bill won seven Emmy awards for writing, performing and producing.
- Bill won a Steve Martin look-alike contest.
- Bill reportedly has a fold-up Periodic Table of Elements and Map of Human Skin Tone in his wallet.
- Bill's favorite sports are baseball, bicycling and ultimate Frisbee.
- Bill doesn't have a favorite element but he does love water.
- Bill's lab coat size is "38 Tall".
- Bill has been a licensed mechanical engineer in Washington since 1983.
- Bill agree's with the change of making Pluto from a planet to a "dwarf planet" despite all the negative outrage.
- Bill married Blair Tindall on February 3 2006. Their marriage was annulled on March 28, 2006. They had no children.
- Bill: (on when his interest in science sparked) Uh, I don't remember. I've always loved it, thought it was the coolest thing you could do with your time.
- Bill: (on the best part of having a show) Not only do I get to imagine ways to do something, but I get to do it, too.
- Bill: I've always loved airplanes and flight. The space program was really important to me as a kid. I still have a photo of Armstrong and Aldrin on the moon in my living room.
- Bill: Humor is everywhere, in that there's irony in just about anything a human does.
- Bill: (Advice to young scientists) Try things then clean up after yourself. Then try some more things and clean that up too.