- In 1987, Matthew was nominated for a Golden Globe in the category of Best Performance by an Actor in a Motion Picture - Comedy/Musical for his lead role in the 1986 comedy Ferris Bueller's Day Off.
- In 2005, Matthew won the Hollywood Film Award in the category of Supporting Actor of the Year.
- Matt weighs roughly 182 pounds.
- Matthew's favorite sport team is the New York Mets.
- Matthew's hobbies include watching spectator sports, bowling, paddle ball, and pingpong.
- Matthew is allergic to horses.
- Matt's dentist once sent Matt a stripper on his birthday.
- On January 9, 2006 Matthew and his Broadway and Movie co-star, Nathan Lane, were awarded a joint star on the Hollywood Walk of Fame. The star is located at 6801 Hollywood Blvd.
- Matt was actually the first choice to play Alex P. Keaton on the sitcom Family Ties, but he didn't want to be committed to a long television run so Michael J. Fox took the role instead.
- Matthew married actress Sarah Jessica Parker on May 19, 1997. The couple are still married today. They have had one child together, a Son named James Wilke Broderick born in Manhattan, New York on October 28, 2002.
- Matt is Polish on his mother's side and Irish on his father's side.
- Matt has two older sisters one of which is named Martha, who's a therapist and Janet who works as a minister. He also has a brother who's named Timothy Britten Parker.
- Matt is the son of actor James Broderick and Patricia Broderick both of whom are deceased.
- Matt played Leopold Bloom in the remake of the movie of the broadway play The Producers with fellow costar Nathan Lane.
- Matthew is close friends with Megan Mullally, with whom he starred in the Broadway musical "How to Succeed in Business Without Really Trying."
- Matthew: (on his young son James) I can just see the little budding gene of a smoker in there. He'll see a cigarette but and say: 'What is that? Why do people smoke?'
- Matthew: I just want the money and the fame and the adoration, and I don't want any of the other stuff.
- Matthew: Having a baby changes the way you view your in-laws. I love it when they come to visit now. They can hold the baby and I can go out.
- Matthew (on a gay kissing scene in an early role): We did only two takes... he wasn't very gentle... and he didn't call me afterwards.
- Matthew: (about his collaborations with Nathan Lane) You don't want to put the whammy on it, you know - we haven't done this yet. But, yeah, it feels like a good match.
- Matt: (about his role in "Godzilla"): All I can really say is I play a scientist, like a bugologist or something ...what the hell am I? I forgot what I am... how embarrassing.
- Matthew: (on Clint Eastwood) I've just always loved him and his big brutal gun.
- Matthew: (about his role in "The Producers"): I probably wouldn't make a good accountant. I don't even understand what my accountant tell me. But the character is a sort of exaggerated version of me he's a little more frightened than I am, everything seems so much bigger to him than it does to me.
- Matt: (on prepairing for his role in "Finding Amanda") It's baffling. I know nothing about gambling. I've barely been to the track. When I was a kid my father took me a few times. As an adult I think I've been twice. I'm not a research person but I'll have to learn about gambling and betting because I don't know anything about it.
