- Anthony is superstitious about wearing green when he plays soccer. He says he always has a bad game when he wears green, and almost always wears a pink jersey when playing soccer.
- Anthony attended Rostrevor College, a Catholic all-male boarding school located in Adelaide, South Australia.
- Anthony was a strong possibility for the role of Tony Soprano on The Sopranos, but did not get the role.
- In the summer of 2004, Anthony under went hip relplacement surgery to repair an injury he sustained in his early soccer playing days.
- 2004 Awards
Emmy nomination - Outstanding Guest Actor in a Comedy Series for Frasier
Emmy nomination - Outstanding Lead Actor in a Drama Series for Without a Trace
Golden Globe - Best Performance by an Actor in a Television Series - Drama for Without a Trace
Golden Satellite Award nomination - Best Performance by an Actor in a Series, Drama for Without a Trace
Golden Starfish Award for Career Achievement for his acting career
Achievement Award at Newport Beach Film Festival - Outstanding Achievement in Acting for Happy Hour
Prism Award - Performance in a Film Festival Award for Happy Hour
Actor nomination at Screen Actors Guild Awards - Outstanding Performance by a Male Actor in a Drama Series for Without a Trace
Actor nomination at Screen Actors Guild Awards - Outstanding Performance by an Ensemble in a Drama Series for Without a Trace shared with: Eric Close, Marianne Jean-Baptiste, Poppy Montgomery, & Enrique Murciano
Best Actor at Verona Love Screen Film Festival for Happy Hour.
- 2002 Awards
Emmy - Outstanding Guest Actor in a Comedy Series for Frasier
FCCA Award - Best Actor - Male for Lantana
- 2001 Awards
AFI Award - Best Actor in a Leading Role for Lantana
FCCA Award nomination - Best Supporting Actor - Male for Looking for Alibrandi
If Award - Best Actor for Lantana
- Anthony has set up two series projects via his Warner Bros. Television-based Last Straw Productions banner. The Eye project, named Damnation, is a comedy that revolves around a deceased man who believes he's wrongly been sent to hell and makes a deal with the devil to recruit souls to the underworld. The second project, The Word is an action drama about a renegade team of whistle-blowers who expose cover-ups and conspiracies.
- In 1993, Anthony received an AFI Award nomination for 'Best Actor in a Lead Role' for his role in The Custodian.
- In 2000, Anthony received an Emmy nomination as 'Outstanding Guest Actor in a Comedy Series' for his role as Daphne's brother in Frasier.
- Anthony received the 1998 Tony Award for 'Best Actor In A Play' for his role in A View From the Bridge
- In the mid 1980s, Anthony was the goalkeeper for both Adelaide City and West Adelaide teams in the National Soccer League in Australia.
- Anthony is a volunteer in the Young Storytellers Program.
- Anthony was previously married to actress Cherie Michan.
- Anthony met his wife, actress Gia Carides, when they both starred in the movie Lucky Break in 1994.
- Anthony attended Norwood Morialta High School in South Australia.
- Anthony has two younger brothers. Michael is a car dealer, while his other brother, Jonathan, is both a licensed doctor and an actor.
- In 2005, Anthony was nominated for a Golden Satellite Award as Best Actor in a Series, Drama for his role in Without a Trace.
- Anthony regrets dropping his Australian accent for American TV roles.
- Anthony filmed a number of scenes as gangster Al Capone in the movie Road to Perdition, but unfortunately all the scenes were omitted.
- Anthony says he was inspired to become an actor by a community theatre performance of William Congreve's Way of the World.
- Anthony is married to Australian actress Gia Carides, who he met whilst jointly starring in the 1994 movie Lucky Break.
- Anthony originally moved to America to pursue a career in teaching.
- Anthony is a part owner of an Australian Soccer club called Sydney FC (Football Club).
- Anthony was listed as one of twelve "Promising New Actors of 1991" in John Willis' Screen World, Vol. 43.
- Anthony is 5'11" tall.
- Anthony welcomed a daughter, with Gia Carides, named Bridget in January of 2003.
- Anthony won Broadway's 1998 Tony Award as Best Actor (Play) for a revival of Arthur Miller's A View from the Bridge.
- Anthony is Italian on his father's side and Dutch on his mother's side.
- Anthony's last name is pronounced La Pah-lia.
- Anthony is the older brother of Jonathan LaPaglia, star of The District. Anthony is also the brother-in-law of actress Zoe Carides.
- Anthony: (When asked if he thinks he could work an actual missing person's case.) Absolutely not. I'm the last person...I can't find my car keys in the morning. Trying to get out of my house is a nightmare. "Where's my wallet? Where are my keys? I have to go find a missing person."
- Anthony: (On Without a Trace) It's hard to come up with interesting stories that you can't second-guess every week. It's a really tough job, to do it in an intelligent way. As an actor, you always want more character-driven stuff. No matter how much they give you, you still want more. I've always felt like the formula for the show is 10 to 15 percent personal and the rest procedural.
- Anthony: (on the role in "Bullets Over Broadway") It was down to Chazz Palminteri and myself for Bullets Over Broadway. Chazz is a good friend of mine, and I'm glad he got the role. If not me, I'm glad it was him!
- Anthony: I like the Baldwin boys a great deal. Alec is super-smart, super-articulate, almost too smart to be an actor.
- Anthony: A lot of people think I'm that guy in Betsy's Wedding, but I'm not. What it is for me is that, on some level, I connect with the character emotionally.
- Anthony: The whole question of God and what God is, and whether it's a blond guy with a beard, I don't know... I don't know that. Do I believe that there's something greater at work than the sum of humanity? Yeah, I think so.
- Anthony: Steve Martin is one of the most intelligent, well-read human beings that I've ever come across. He is equally as funny off screen as he is on. But he also has a very intellectual side, and he's a really nice human being. We actually become good friends.
- Anthony: We do have a fish named Shallowy. My daughter named it. She's three!
