- Sean's brother is actor, Chad W. Murray, who also appeared on the TV series NCIS in the first season but before Sean was a guest-star or a series regular.
- Sean Murray's mother is the fourth wife of American television producer and screenwriter Donald Bellisario.
- Sean Murray holds a dual US/Australian citizenship.
- Sean is married to Carrie James (since November 26, 2005), and they have a daughter, Caitlyn Melissa Murray ( born May 3, 2007).
- During training for his role as an NCIS special agent, Sean visited a federal law enforcement training center in Georgia, taking driving courses and practicing on the shooting range.
- Sean appeared in the 1996 TV movie Fall Into Darkness as the character of Jerry, opposite Tatyana Ali and Jonathan Brandis.
- Sean had a small role in the 1997 TV movie The Sleepwalker Killing as Christopher Lane. The TV movie was actually spun-off from the TV series Unsolved Mysteries.
- Sean played Nick Keeper in the 2001 TV movie Spring Break Lawyer.
- Sean currently lives in Sherman Oaks, California.
- Sean's stepbrother, Michael Bellisario, appeared on episodes of NCIS as Chip, and stepsister, Troian Avery Bellisario played his sister Sarah on an episode of NCIS.
- Sean attended Bonita Vista Junior High in Chula Vista, California.
- Sean's first role was in the 1991 TV movie Backfield in Motion where he played the role of Joe Jr.
- Sean Murray appeared in the 1993 Disney film Hocus Pocus as Thackery Binx, but did not provide the voice for the cat his character was turned into.
- Sean was born in Bethesda, Maryland, USA.
- Sean rebuilds computers and serves as a technical consultant regarding computers issues on the TV series NCIS.
- Before becoming a series regular on NCIS, Sean appeared in several season 6 episodes of JAG as 'Danny Walden'. He also played 'Ensign Guiltry' in the earlier season 4 episode Innocence.
- Sean's favorite music artists are Aphex Twin and Angelo Badalamenti.
- He is a fan of David Lynch's films.
- Sean attended Bonita Vista Junior High (now Bonita Vista Middle) in Chula Vista, California.
- Sean played Henry in the 1996 TV movie The Lottery.
- Sean can be contacted via his agent:
Stone Manners Agency
8436 W 3rd Street
Suite 740
Los Angeles, CA 90048