- Sarah is expecting her first child with her fiancee Jamie Afifi.
- Her first appearance on television was when she ten and worked in a commercial for toilet paper.
- Sarah is very scared of the needles. She claims to pass out everytime when taken blood from.
- Sarah always wanted to be on an athlete and on a sports team.
- Sarah loves eating pumpkins.
- Chalke graduated from Handsworth High School in North Vancouver in 1994.
- In the 22nd of January, 2006, Sarah appeared on the cover page of the magazine PDTV. She was also featured in the August 2004 issue of InStyle magazine.
- Sarah's mother was from Germany and her father from Canada, which makes her half German and half Canadian.
- Sarah was granted American citizenship in April 2008.
- She is a vegetarian.
- In 2008, Sarah became the new face for Hanes No Ride Up Panty line.
- In 2005, Sarah played the role of Maria in Create Fate, a play by Etan Frankel. From April to May that same year, she appeared as Hannah in the Off-Broadway production of Modern Orthodox.
- Sarah won $500 from the Scrubs creator Bill Lawrence when she completed the "Scrubs Factor" dare of going to Starbucks in fishnets, heels and feather fans. She ended up standing in line for about twenty minutes.
- In 2002, Sarah appeared in the print ads for America's Milk Processors "got milk?" campaign alongside Scrubs co-star Zach Braff and Donald Faison.
- In 2007, Sarah ranked #77 on Askmen.com's list of "Top 99 Women".
- Sarah's favorite episode of Scrubs was "My Life in Four Cameras" which was partly taped in front of a live studio audience.
- Sarah lost both her aunt and her grandmother to breast cancer. As a result, she decided to promote breast cancer awareness by starring in Why I Wore Lipstick to my Mastectomy.
- Sarah does a "killer" robot dance.
- Sarah's character on Scrubs went bungee jumping, but it was actually her double who performed the stunt. In real life, however, Sarah has gone hang-gliding.
- Sarah's first on-camera kiss was in the 1992 made-for-television movie City Boy.
- She is close friends with Scrubs co-star Zach Braff. She is also very good friends with actors Christa Miller and Nicole Sullivan who have also appeared several times on the show.
- While starring in Scrubs, Sarah has appeared in nine The More You Know public service announcements for NBC. Her topics were anti-prejudice, child abuse and neglect prevention, designated drivers, emergency planning, family communication, second anti-prejudice, seat belts, anti-smoking, and substance abuse.
- In December 2006, she got engaged to the entertainment lawyer and fellow Canadian Jamie Afifi. Jamie proposed to her during a vacation at the Grand Wailea Resort in Hawaii. They have been dating since 2003.
- At 16, she became a reporter on Canadian children's show KidZone.
- Nominations:
2000 - Gemini Award for "Best Performance by an Actress in a Continuing Leading Dramatic Role" for Nothing Too Good for a Cowboy (1998)
2003 - Teen Choice Award for "Choice TV Actress - Comedy" for Scrubs (2001)
2004 & 2006 - TV Land Award for "The Most Irreplaceable Replacement" for Roseanne (1988)
- Sarah's parents, Doug and Angie Chalke, run a child adoption agency. Her father, Doug is also a professional lawyer. Sarah has one younger sister named Piper and on older sister named Natasha.
- Sarah speaks fluent French and German.
- During Scrubs hiatus in 2005, Sarah starred in two movies. The first was Alchemy, a romantic comedy starring Tom Cavanagh (star of Ed, also known for his recurring role as Dan Dorian, J.D's brother on Scrubs). The other movie is Cake, starring Heather Graham (has a recurring role in Scrubs as Dr. Molly Clock), Cheryl Hines (appeared as Paige Cox on the show), and Taye Diggs. Cake is also a romantic comedy and is directed by Nisha Ganatra.
- She is known for being a klutz and has managed to get injured a number of times including sprained ankles, torn ankle tendons, torn ligaments, broken bones and more.
- She is one of the few from the Scrubs cast who can’t sing, something she and her older sister found out when they played in musicals at an early age.
- At times on the set of Scrubs. Sarah is referred to as "Becky #2" in response to her being the second "Becky" on Roseanne.
- Played Markie Post's daughter in the horror film I've been waiting for You (1998) and Markie Post also plays her mom as a guest star on Sarah's sitcom, Scrubs.
- She has three dogs named Harley, Tankers and Lola. Lola is a brown Labrador and was a gift from the Scrubs cast.
- Her father is a lawyer and both her parents are mediators who also run a child adoption agency. Two years ago, she accompanied her parents to China to coordinate the adoption of several orphans there.
- In her leisure time, Chalke prefers cooking with friends (especially Thai and sushi), playing the guitar, hiking, skiing, snowboarding, kayaking and reading. She's also a skiing instructor.
- She volunteers at a hospice for terminally ill children and works for the Audrey Hepburn Children's Fund.
- Sarah played older sister of Sara Gilbert on Roseanne, but is younger in real life.
- Sarah is 5 feet 8 inches (1.73 metres) tall. She has blond hair and blue eyes.
- In 2000, Sarah announced she'd like to take a break from acting and attend college. Apparently, she changed her mind since she has been working on Scrubs since 2001.
- Sarah: I don't smoke, I try to eat right, and I love doing yoga and going for hikes with my dog.
- Sarah: (in a 2006 interview) I went overnight from carnivore to vegan at 12. That was my biggest overhaul. I've slowly gone back, later on in life, to fish and then chicken and then, last year, red meat.
- Sarah: Human beings are not meant to lose their anonymity and privacy.
- Sarah: I think that as is true in this industry, everything gets blown out of proportion because it's more fun for people to read about. It's even more fun to read about if the stories get wilder and wilder.
- Sarah: Your home should be your home. People shouldn't be allowed to use whatever crazy lenses they use to catch you waking up in the morning.
- Sarah: I don't think when people sign up for a life of doing something they love to do they should have to sign up for a complete loss of privacy. I understand a little loss of privacy coming with the job.
- Sarah: (on the set of "Scrubs") We have such a good time working together. It makes such a difference going to work every day for 14 hours and being able to hang out and have a good time.
- Sarah: (talking about "Scrubs") I would be sad if it ended now. It's been the best job I've had by a long shot, especially creatively because the writing is so good. Every week I get the script and I laugh out loud and get excited for the different stuff we get to do.
- Sarah: (talking about "Scrubs") I think it's because it's so different and it takes risks. Plus, it's really smart humor. It gives the audience credit in terms of not needing to tell them when to laugh. I love that about the show. There's no laugh track.
- Sarah: I've fallen in love with New York City! It was the first time I ever got to stay in New York for an extended period of time. I really enjoyed it.
- Sarah: (about "Scrubs") Well, we film it on the site of what used to be a real hospital for 30 years. So many people continue to think it's still functional.
- Sarah: What doctor does not need platform heels and dark black eyeliner to treat their patients?
- Sarah: The first time I lived in L.A. I was too young. I really wanted to be back home in Vancouver.
- Sarah: (about how "Scrubs" changed her life) Before getting Scrubs, I had always threatened myself I'd have to become a dental hygienist if I quit acting - to me, that would be the hardest job. I would tell myself, 'Just stick it out for a little longer.' It definitely was a turning point.
- Sarah: (on "Scrubs") When I first opened the script and read the pilot, I was laughing out loud. I just hadn't seen anything on the air like it and I wanted to be a part of it.
- Sarah: (about "Scrubs") I'm having the time of my life. I've never looked forward to going to work so much every day. I'm loving it; it's great. It's what I love to do and I wouldn't want to be doing anything else.
