- Christopher played the role of "Paul" in the movie Intellectual Property.
- Christopher played a small role in the film Beethoven's 2nd. His brother Danny had a bigger role in the same film.
- Christopher played the roles of "Gus" and "Augustus" in the film Arcadia
- Chris smokes a lot but he doesn't worry about it.
- Christopher stole a "STOP" traffic signal when he was younger.
- Christopher met Jane Kaczmarek ("Lois" in Malcolm in the Middle) before working on the series, when they were acting in a show called Youth in Revolt which never aired.
- Christopher is sometimes credited as Kuk Tak-Chiu.
- Christopher Masterson is sometimes credited as Vincent Kok.
- Christopher earned the Best Young Ensemble Cast in Television YoungStar Award for his role in Malcolm in the Middle.
- Christopher's mother is called Carol Masterson.
- Christopher's father is called Peter Masterson.
- When he was younger, Christopher stole a fire hydrant. He still has the hydrant in his room as a trophy.
- Christopher dated actress Hillary Duff.
- As of 2006 he lives with the actress Laura Prepon.
- Christopher is a member of the Church of Scientology.
- Chris has a younger sister, Alanna, from his mother's second marriage, and a younger brother, Will Masterson, from his father's second marriage.
- Christopher is 5'10" (1.78 m).
- Chris has two brothers: Daniel "Danny" Masterson (best known for his role as Stephen Hyde on That '70s Show) and Jordan "Jordy" Masterson.
- Chris is currently dating Laura Prepon ("Donna", That '70s Show).
