Allegra Geller (Jennifer Jason Leigh) is the greatest game designer in the world and testing her latest virtual reality game, eXistenZ, with a focus group in what appears to be a church. To play...

Allegra Geller (Jennifer Jason Leigh) is the greatest game designer in the world and testing her latest virtual reality game, eXistenZ, with a focus group in what appears to be a church. To play the game, you must plug the 'pod', the organic future version of a gaming console, into a 'bio-port' near the bottom of your spine. As they begin, she is attacked by a fanatic assassin armed with a bizarre organic gun which is undetectable by security. Fearing other assassins, she flees with marketing trainee, Ted Pikul (Jude Law), who is suddenly assigned as her bodyguard. Unfortunately, her pod, containing the only copy of the eXistenZ game, is damaged in the assassination attempt. To inspect it, she talks a reluctant Pikul into accepting a bio-port in his own body so he can play the game with her. The events leading up to this, and the resulting game lead the pair on a strange adventure where it becomes impossible to tell if their actions are their own, or the will of the game, and impossible to tell if they are in the game, or in the real world.